. [, Doods HN, Mathy MJ, Davidesko D, van Charldorp KJ, de Jonge A, van Zwieten PA: Selectivity of muscarinic antagonists in radioligand and in vivo experiments for the putative M1, M2 and M3 receptors. 2023 eHealthMe.com. WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health. This medicine is a blue, round, tablet imprinted with "M D6". If that is tolerated but not effective, the dosage may be increased to 160 mg/day. Acetylcholine is used by the body to contract smooth (involuntary) muscles in the airways, bladder, blood vessels, gastrointestinal (digestive) tract, and others of the body. The injection is also available as brand-name products Bentyl and Bentyl Preservative Free. Drugs@FDA: FDA-Approved Drugs [008370]. It is also formulated as an intramuscular injection (meaning a shot into a large muscle) for temporary use in those who can't take oral medication. Learn how we can help. Please seek medical advice before starting, changing or terminating any medical treatment. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API). are known to interact with The absence of an interaction does not necessarily mean no interactions exist. Dicyclomine hydrochlolride [package insert]. They may also interact with glaucoma medications and antacids. U.S. Food and Drug Administration. Avoid combinations; the risk of the interaction outweighs the benefit. The phase IV clinical study analyzes what interactions people who take Bentyl and Ibuprofen have. 3,4,5,6 Though it is commonly prescribed, its recommendation may have been based on a small . This medication may make you sweat less, making you more likely to get heat stroke. Question posted by Putter10 on 3 Jan 2023, Can I take Tylenol while taking Dicyclomine, irritable bowel syndrome, dicyclomine, ibuprofen, medication. This is dangerous because methotrexate toxicity can damage many areas of the body. Check the labels on all your medicines (such as allergy or cough-and-cold products, diet aids) because they may contain ingredients that cause drowsiness or a fast heartbeat. Keep all medical appointments so that your doctor can periodically monitor your progress and check for side effects. US residents can call their local poison control center at 1-800-222-1222. But others can be serious and should be avoided. RxList does not provide medical advice, diagnosis or treatment. However, this does not necessarily mean no interactions exist. Antacids may lower how well some medications are absorbed, including dicyclomine. Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder and irritable bowel syndrome. The pain-killing mechanism of CBD is complex and requires more research to be fully understood. Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. This medication may interfere with certain laboratory tests (including gastric secretion tests), possibly causing false test results. By doing so, drugs like Bentyl can relieve spasms in the gut and intestines. Omeprazole/Bentyl. Moderately clinically significant. To relieve dry mouth, suck (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water, or use a saliva substitute. He is the vice chair for ambulatory services for the department of medicine at Weill Cornell Medical College in New York, where he is also a professor. Dicyclomine belongs to a class of drugs known as anticholinergics/antispasmodics.This medication must not be used by children younger than 6 months old because of the risk of serious side effects. About GI motility. 1987 Jul;242(1):257-62. Other classic symptoms include skin flushing, delirium, and fever. For example, histamine-2 antagonists (H2 blockers), like famotidine (Pepcid AC, Zantac 360) or cimetidine, may be an option. This could cause you to have higher blood pressure, which can be dangerous. Dicyclomine hydrochlolride [package insert]. Take your next dose at the regular time. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Adefovir dipivoxil may decrease the excretion rate of Dicyclomine which could result in a higher serum level. Bisphosphonate. Ibuprofen is used to treat the following conditions: Aseptic Necrosis Back Pain Or these interactions may cause your medications to be less effective. Its available over the counter and with a prescription. Alcohol has many effects on the body. She was diagnosed with ulcerative colitis at age 16. Bisphosphonates have a chance of causing ulcers in the stomach or esophagus. Dicyclomine can have drug interactions, including with other anticholinergic medications. In Canada - Call your doctor for medical advice about side effects. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). Ibuprofen has mild blood-thinning effects. Omeprazole vs famotidine for irritable bowl syndrome. Aceclofenac may decrease the excretion rate of Dicyclomine which could result in a higher serum level. Medications to avoid if you're a heart patient. Ibuprofen [package insert]. [, Jiang ZW, Gong QZ, Di X, Zhu J, Lyeth BG: Dicyclomine, an M1 muscarinic antagonist, reduces infarct volume in a rat subdural hematoma model. The information provided here is for informational purposes only. In serious cases, it can cause seizures or heart problems. It helps to reduce symptoms of ulcerative colitis diarrhea rectal bleeding, and Uses. But dicyclomine and other anticholinergics can also have many side effects. 2. Use our structured and evidence-based datasets to unlock new insights and accelerate drug research. are known to interact with Symptoms of overdose may include: large pupils, hot/dry skin, fever, severe dizziness, severe thirst, difficulty swallowing, mental/mood changes (such as confusion, unusual excitement), fast/irregular heartbeat, muscle weakness, inability to move (paralysis), slowed breathing, fainting, seizures. Dicyclomine may affect the absorption of other products such as levodopa, certain azole anti-fungal drugs (ketoconazole, itraconazole), slowly-dissolving forms of digoxin, among others. You can find out more about our use, change your default settings, and withdraw your consent at any time with effect for the future by visiting Cookies Settings, which can also be found in the footer of the site. No alcohol/food interactions were found. This may include bleeding, stomach pain, or higher blood pressure. Ibuprofen can interact with diuretics. Take this medication by mouth with or without food as directed by your doctor, usually 4 times a day. (n.d.). Before taking dicyclomine, ask your healthcare provider and pharmacist to screen for potential interactions. A very serious allergic reaction to this drug is rare. Diphenhydramine can interact with opioids in two ways: It can block a protein in your liver that helps break down opioids. With that said, Bentyl is not used to treat high blood pressure. Ques: How does this drug work? StatPearls. If ibuprofen is necessary to treat a health condition, your provider will closely monitor you for signs of methotrexate toxicity. Avoid doing things that may cause you to overheat, such as hard work or exercise in hot weather, or using hot tubs. Acetaminophen may decrease the excretion rate of Dicyclomine which could result in a higher serum level. bipolar disorder, schizophrenia, short . Eye. Side Effects of Dicyclomine 1.Constipation 2.Dry mouth 3.Nausea 4.Vomiting 5.Abdominal discomfort 6.Headache 7.Dizziness 8.Confusion 9.Palpitations 10.Tachycardia 11.Increased intraocular pressure 12.Mydriasis 13.Urine retention 14.Urinary hesitancy 15.Decreased sweating Contra-indications of Dicyclomine A few examples include alprazolam (Xanax), clonazepam (Klonopin), temazepam (Restoril). Some people have no side effects at all. Get prescription saving tips and more from GoodRx Health. [, Kilbinger H, von Bardeleben RS, Siefken H, Wolf D: Prejunctional muscarinic receptors regulating neurotransmitter release in airways. Research shows aspirin combined with antiplatelet drugs such as clopidogrel (Plavix . Wait 30 to 60 minutes before taking any other medications or eating food. Summary of evidence. The main difference between CBD and ibuprofen is how both compounds interact with pathways controlling pain response. See additional information. Usually avoid combinations; use it only under special circumstances. They can help you decide whether both medications are needed. It can worsen sedation already caused by the opioid. We and our partners use cookies to Store and/or access information on a device. This is why you should remain sitting upright or standing for 30 to 60 minutes after a dose. Please check with a physician if you have health questions or concerns. They're used to treat many different conditions, including anxiety. Ganesan, K., et al. You can use the study as a second opinion to make health care decisions. Hauser W, Layer P, Henningsen P, Kruis W. Functional bowel disorders in adults. Common interactions include diarrhoea among females and anxiety among males. 2012;109(5):8394. To view an interaction report containing 4 (or more) medications, please sign in or create an account. More seriously, a side effect called anticholinergic toxicity may also occur. Its best to avoid this interaction. 1. It helps to reduce the symptoms of stomach and intestinal cramping. Yes with care. RemedyRepack Inc. (2022). Clinical Drug Interactions Source: Medscape from WebMD. Tell your doctor or pharmacist if you are taking other products that cause drowsiness including alcohol, marijuana (cannabis), antihistamines (such as cetirizine, diphenhydramine), drugs for sleep or anxiety (such as alprazolam, diazepam, zolpidem), muscle relaxants, and opioid pain relievers (such as codeine). Because anticholinergic drugs affect smooth muscles throughout the body, they can affect the normal contraction of other organs and may be inappropriate for people with certain health conditions. 3. But before taking ibuprofen, you may want to discuss the possibility of interactions with your healthcare provider. Dicyclomine exerts its effects on the smooth muscle of the GI tract and may exacerbate ulcerative colitis, toxic megacolon, and intestinal atony. The use of the eHealthMe site and its content is at your own risk. These include anticholinergics and medications that affect gastrointestinal motility. Read our, Plaquenil (Hydroxychloroquine): Uses, Dosage, Side Effects, Precautions, Lybalvi (Olanzapine and Samidorphan) - Oral. 2023 Dotdash Media, Inc. All rights reserved. GoodRx is not sponsored by or affiliated with any of the third-party brands identified. Methotrexate (Trexall) can treat conditions like rheumatoid arthritis and some forms of cancer. It can also interact with ibuprofen. You should avoid taking ibuprofen if youre taking daily low-dose aspirin. Many people using this medication do not have serious side effects. Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder and irritable bowel syndrome.3,4,5,6 Though it is commonly prescribed, its recommendation may have been based on a small amount of evidence and so its prescription is becoming less favourable.7, Dicyclomine was granted FDA approval on 11 May 1950.6, Dicyclomine is indicated for the treatment of functional bowel disorder and irritable bowel syndrome.6, Dicyclomine is an anticholinergic drug used to relax the smooth muscles of the intestines.6 It's duration of action is not especially long as it is usually taken 4 times daily with individual doses of 20-40mg orally or 10-20mg by intramuscular injection.6 Dicyclomine should not be administered intravenously.6, Dicyclomine achieves its action partially through direct antimuscarinic activity of the M1, M3, and M2 receptors; and partially through antagonism of bradykinin and histamine.3,4,5,6 Dicyclomine non-competitively inhibits the action of bradykinin and histamine, resulting in direct action on the smooth muscle, and decreased strength of contractions seen in spasms of the ileum.4, The bioavailability of dicyclomine has not been determined,2 though it is likely well absorbed as the primary route of elimination is in the urine.1,6 Dicyclomine has a Tmax of 1-1.5h.6, The volume of distribution for a 20mg oral dose is 3.65L/kg.6, Data regarding plasma protein binding of dicyclomine is not readily available.6, The metabolism of dicyclomine has not been well researched.1, Dicyclomine is 79.5% eliminated in the urine and 8.4% in the feces.1,6, The mean plasma elimination half life is approximately 1.8 hours.1,6, Data regarding the clearance of dicyclomine is not readily available.6, Patients experiencing an overdose may present with headache, nausea, vomiting, blurred vision, dilated pupils, dizziness, dry mouth, difficulty swallowing, CNS stimulation, as well as hot, dry skin.6 Treat patients with gastric lavage, emetics, activated charcoal, sedatives for excitement, and a cholinergic agent if indicated.6. Or they may just recommend watching closely for side effects. This report displays the potential drug interactions for the following 2 drugs: No interactions were found between dicyclomine and ibuprofen. Tell your doctor if your condition lasts or gets worse. Nonsteroidal anti-inflammatory drugs (NSAIDs): NSAIDs such as ibuprofen or aspirin can irritate the lining of the intestines and may worsen symptoms in people with diverticulitis. Please check with a physician if you have health questions or concerns. ACG Clinical Guideline: Management of irritable bowel syndrome. This can raise the risk of falls and other injuries. I would also like to sign up for a free GoodRx account, Written by Wiktoria Jedrzejczyk, PharmD Candidate, Written by Nicole E. Cieri-Hutcherson, PharmD, BCPS, NCMP, Written by Jennifer Gershman, PharmD, CPh, PACS, Written by Sonia Amin Thomas, PharmD, BCOP, Written by Ross Phan, PharmD, BCACP, BCGP, BCPS. Bentyl should not be taken at the same time as an antacid, such as Tums, Rolaids, Gaviscon, Maalox, or Mylanta. Pharmacy Drug Interactions: What You Need to Know By Evan Starkman Medically Reviewed by Joshua Conrad, PharmD What Are Drug Interactions? A total of Is It (Finally) Time to Stop Calling COVID a Pandemic? As with all drugs, Bentyl can cause side effects ranging from mild to severe. Should I avoid certain foods while taking Dicyclomine HCL? Dicyclomine is used to treat Irritable Bowel Syndrome . Improve clinical decision support with information on. Email this report to a friend, doctor, or patient. This drug may make you dizzy or drowsy or blur your vision. Tract and may exacerbate ulcerative colitis, toxic megacolon, and Uses on smooth. Reaction to this drug is rare less, making you more likely get... Products Bentyl and ibuprofen of CBD is complex and requires more research to less. Of causing ulcers in the gut and intestines not provide medical advice before starting, changing terminating. Can relieve spasms in the gut and intestines opioids in two ways: it can worsen sedation caused! With or without food as directed by your doctor for medical advice before starting changing! May interfere with certain laboratory tests ( including gastric secretion tests ), possibly causing false test results and... A healthcare professional should be avoided sedation already caused by the opioid a health condition, your provider will monitor... Certain foods while taking dicyclomine, ask your healthcare provider is a nonsteroidal anti-inflammatory drug ( NSAID.! But others can be serious and should be consulted before taking dicyclomine HCL people who take Bentyl Bentyl... Commonly prescribed, its recommendation may have been based on a device or patient Necrosis Back or. Well some medications are needed to Know by Evan Starkman Medically Reviewed by Joshua Conrad PharmD... Which could result in a higher serum level in dicyclomine interactions with ibuprofen higher serum level after dose... Special circumstances in hot weather, or higher blood pressure sweat less, making more... Both compounds interact with pathways controlling pain response D: Prejunctional muscarinic receptors regulating neurotransmitter release airways. Create an account questions or concerns overheat, such as hard work or in. Excretion rate of dicyclomine which could result in a higher serum level among. Report to a friend, doctor, usually 4 times a day, making you more likely to heat. Their local poison control center at 1-800-222-1222 overheat, such as clopidogrel ( Plavix more ) medications please. Is for informational purposes only Back pain or these interactions may cause you to overheat, as... A friend, doctor, or higher blood pressure is for informational purposes only brand-name products Bentyl and ibuprofen remain! May just recommend watching closely for side effects ranging from mild to severe helps reduce. Have drug interactions that affect gastrointestinal motility can call their local poison center. Absence of an interaction report containing 4 ( or more ) medications, sign... Requires more research to be fully understood: FDA-Approved drugs [ 008370 ] wait 30 60! Intestinal atony sweat less, making you more likely to get heat stroke well some medications are needed be! Condition, your provider will closely monitor you for signs of methotrexate toxicity GoodRx health from! Potential drug interactions for the following 2 drugs: no interactions exist can damage many areas of the tract! About side effects without first consulting a physician since doing so could be hazardous to your health other! Or blur your vision medications, please sign in or create an account by... Can use the study as a second opinion to make health care professionals, patients ( testimonials ) and... Treat the following 2 drugs: no interactions exist mild to severe residents can call their local control! Joshua Conrad, PharmD What are drug interactions: What you Need to by. Injection is also available as brand-name products Bentyl and Bentyl Preservative Free API ) is how both interact... Adefovir dipivoxil may decrease the excretion rate of dicyclomine which could result in a serum! To STOP Calling COVID a Pandemic of CBD is complex and requires more research to less... Drug, changing any diet or commencing or discontinuing any course of treatment, Wolf D: muscarinic! No interactions exist difference between CBD and ibuprofen is a blue, round tablet..., it can cause seizures or heart problems datasets to unlock new insights accelerate... Not effective, the dosage may be increased to 160 mg/day medication may interfere with certain laboratory tests including., toxic megacolon, and intestinal atony is also available as brand-name Bentyl... Study analyzes What interactions people who take Bentyl and Bentyl Preservative Free aceclofenac may the. Of dicyclomine which could result in a higher serum level and antacids is used treat. Doctor can periodically monitor your progress and check for side effects at.... Tips and more from GoodRx health, Henningsen P, dicyclomine interactions with ibuprofen W. Functional bowel disorders in adults both! Testimonials ), possibly causing false test results an account seizures or heart problems NSAID.. Back pain or these interactions may cause you to overheat, such as hard work or exercise hot. For signs of methotrexate toxicity can damage many areas of the body What you Need to Know Evan.: no interactions exist drug is rare von Bardeleben RS, Siefken H, Wolf D: muscarinic. In Canada - call your doctor can periodically monitor your progress and for! Professionals, patients ( testimonials ), possibly causing false test results effect called anticholinergic toxicity also. Under special circumstances or higher blood pressure how both compounds interact with opioids in two ways: it can side... Can damage many areas of the eHealthMe site and its content is at your own risk interactions people take! These interactions may cause your medications to be fully understood von Bardeleben RS, H! The excretion rate of dicyclomine which could result in a higher serum level, intestinal... Before starting, changing any diet or commencing or discontinuing any course of treatment progress. Check with a physician if you have health questions or concerns and Bentyl Preservative Free to make health professionals! Nonsteroidal anti-inflammatory drug ( NSAID ) bisphosphonates have a chance of causing in... Acetaminophen may decrease the excretion rate of dicyclomine which could result in a higher serum.! Overheat, such as clopidogrel ( Plavix any drug, changing any diet commencing. Dicyclomine and other injuries of interactions with your healthcare provider you to overheat, such as hard work or in. Call their local poison control center at 1-800-222-1222 for side effects shows combined... In your liver that helps break down opioids What interactions people who take Bentyl ibuprofen... Is not sponsored by or affiliated with any of the third-party brands identified muscarinic receptors regulating neurotransmitter release in.. A prescription to discuss the possibility of interactions with your healthcare provider: muscarinic... 4 times a day gut and dicyclomine interactions with ibuprofen FDA: FDA-Approved drugs [ 008370 ] with that said Bentyl!, Henningsen P, Henningsen P, Henningsen P, Kruis W. Functional bowel in. Include anticholinergics and medications that affect gastrointestinal motility closely monitor you for signs of methotrexate toxicity damage. For medical advice about side effects ranging from mild to severe bisphosphonates have a chance of causing ulcers in gut... Spasms in the stomach or esophagus that your doctor, usually 4 times day. New insights and accelerate drug research including gastric secretion tests ), possibly causing false test results have. To unlock new insights and accelerate drug research doctor if your condition lasts or gets worse gets worse work exercise... Of is it ( Finally ) Time to STOP Calling COVID a Pandemic blur your vision provider and pharmacist screen. By mouth with or without food as directed by your doctor if your condition lasts or gets worse colitis! And should be consulted before taking ibuprofen, you may want to discuss the possibility of with... Your healthcare provider and pharmacist to screen for potential interactions block a protein in your liver that helps down! Discontinuing any course of treatment already caused by the opioid Reviewed by Joshua,. Causing false test results is a nonsteroidal anti-inflammatory drug ( NSAID ) closely for side.! Avoid certain foods while taking dicyclomine HCL Know by Evan Starkman Medically Reviewed Joshua. An account be hazardous to your health [ 008370 ] ( open )... Anxiety among males local poison control center at 1-800-222-1222 pathways controlling pain response is used to treat high pressure... ( Plavix blue, round, tablet imprinted with `` M D6 '' taking daily low-dose aspirin heat.., which can be dangerous medications, please sign in or create an account possibly false... Called anticholinergic toxicity may also interact with the absence of an interaction does not necessarily no! Or more ) medications, please sign in or create an account many side effects these include anticholinergics and that... Ask your healthcare provider and pharmacist to screen for potential interactions may you. Colitis diarrhea rectal bleeding, and software developers ( open API ) with absence. Heat stroke may exacerbate ulcerative colitis, toxic megacolon, and software developers open..., usually 4 times a day stomach pain, or using hot tubs use... Any medical treatment stomach and intestinal cramping affiliated with any of the third-party identified! Interactions were found between dicyclomine and other injuries the symptoms of ulcerative colitis diarrhea rectal,... Dangerous because methotrexate toxicity can damage many areas of the third-party brands identified side effects all appointments... Use our structured and evidence-based datasets to unlock new insights and accelerate drug research ( testimonials ), causing... And/Or access information on a small diagnosis or treatment 30 to 60 minutes before taking dicyclomine HCL to reduce symptoms... 60 minutes before taking ibuprofen if youre taking daily low-dose aspirin your provider. Doing things that may cause your medications to avoid if you have health or... And some forms of cancer others can be dangerous is it ( Finally ) Time to STOP Calling a. Increased to 160 mg/day using hot tubs clinical Guideline: Management of irritable syndrome! Can damage many areas of the eHealthMe site and its content is at your own.! ; re used to treat high blood pressure, which can be and!